Synthesis of N-Arylsulfonamides
Rylan Lundgren describes the copper-catalyzed synthesis of N-arylsulfonamides.
Synthesis of N-Arylsulfonamides by a Copper-Catalyzed Reaction of Chloramine-T and Arylboronic Acids at Room Temperature: B. Ouyang, D. Liu, K. Xia, Y. Zheng, H. Mei, G. Qiu Synlett 2017, DOI: 10.1055/s-0036-1590978
The arylsulfonamide moiety is widespread among drugs and bioactive compounds. The classical and most used method for preparing the title compounds is the coupling between sulfonyl chlorides and aromatic amines which, however, are often highly toxic, carcinogenic and mutagenic. Recently, the group of Dr. Banlai Ouyang (Nanchang Normal University, P. R. of China), in collaboration with Dr. Guanyinsheng Qiu (Jiaxing University, P. R. of China), reported a new approach to the title compounds.