Synthesis of 1-Alkylisoquinolines via Radical Cyclization
Metal-Free Radical Cyclization of Vinyl Isocyanides with Alkanes: Synthesis of 1-Alkylisoquinolines: D. Xue, Y. Xue, H. Yu, L. Shao
Synthesis 2018, DOI: 10.1055/s-0037-1610661
Traditional synthetic approaches to the biologically important isoquinoline core – such as Bischler–Napieralski, Pomeranz–Fritsch and Pictet–Spengler reactions – often rely on the use of harsh reaction conditions, which are not always compatible with densely functionalized molecules. Recently, the group of Professor Liming Shao from Fudan University (Shanghai, P. R. of China) described the use of isocyanides, which are versatile building blocks that can be employed as building blocks for constructing heterocycles, for accessing 1-alkylisoquinolines.