Synthesis of the Polyunsaturated Fatty Acid Amide δ-Sanshool and Analogues
Claudia Mugnaini describes the synthesis of the polyunsaturated fatty acid amide δ-sanshool and analogues thereof.
Total Synthesis of δ-Sanshool and Analogues Thereof: C. Mugnaini, F. Corelli
Synthesis 2016, 48, DOI: 10.1055/s-0035-1561580
Polyunsaturated fatty acid amides (FAAs) are important natural compounds displaying a wide range of biological activities. Some FAAs are pharmacologically active components of natural extracts which have been used in traditional medicine. One of them is δ-sanshool – isolated and identified for the first time in 1997 – which is present in extracts of Rutaceae species, whose extracts have been used to treat toothaches or as food spices. Now, Professors Claudia Mugnaini and Federico Corelli from the University of Siena (Italy) have described a synthesis of δ-sanshool and some of its analogues.
Professor Mugnaini said: “Nineteen years after its isolation from Budo-Zanthoxylum fruit, we have described the synthesis of δ-sanshool, a molecule which could represent the prototype of new anti type-1 diabetes drugs.”