Hexamethyldisilathiane as a Sulfur Source for the Synthesis of Diaryl Sulfides
Norio Sakai uses hexamethyldisilathiane as sulfur source for the synthesis of diaryl sulfides.
Copper-Catalyzed Production of Diaryl Sulfides Using Aryl Iodides and a Disilathiane: Y. Ogiwara, H. Maeda, N. Sakai
Synlett 2018 DOI: 10.1055/s-0036-1591723
Diaryl sulfides are very interesting compounds having a variety of applications in drug discovery, fine chemicals and material sciences. The group of Professor Norio Sakai from the Tokyo University of Science (Japan) has been active in the area of thioether synthesis for some time and had previously described the use of elemental sulfur and hydrosilanes for producing the target compounds. Recently, in a new important development, the group has reported a versatile Cu(I)-catalyzed synthesis of diaryl sulfides.
Professor Sakai said: “This paper describes a disilathiane, (Me3Si)2S, as a new sulfur source for a copper-catalyzed carbon–sulfur double bond formation that transforms aryl iodides into diaryl sulfides. This first attempt provided various types of symmetrical diaryl sulfides efficiently.”