• Lydia C. Gilday is the winner of the SYNFACTS poster prize, awarded at the ISXB-1.


SYNFACTS poster prize awarded at ISXB-1

Lydia C. Gilday received at ISXB-1 a SYNFACTS poster prize for her poster on 'Solution-Phase Applications of Halogen Bonding: Anion Recognition and Templated Self-Assembly' (by Lydia C. Gilday, Paul D. Beer; Inorganic Chemistry Laboratory, University of Oxford; Oxford, UK)

Interlocked molecules have captured chemists’ imagination owing to their non-trivial topology and promising potential as molecular machines and chemical sensors.1 The synthesis of such sophisticated architectures is a challenge and requires the implementation of imaginative templation strategies. These synthetic methodologies typically employ a combination of complementary Lewis acid–base, electrostatic, and hydrogen-bonding interactions for component assembly.2 Halogen bonding (XB) is the attractive, highly directional, non-covalent interaction between an electron-deficient halogen atom and a Lewis base,3 and the scope of XB in solid-state crystal engineering has been intensively explored for a number of years. In spite of the complementary analogy to ubiquitous hydrogen bonding, however, it is only recently that investigations into the use of solution-phase XB interactions for molecular recognition, self-assembly and catalysis has resulted in this field developing rapidly.4 Indeed, in conjunction with anion templation, we have used XB to assemble interpenetrated and interlocked molecular frameworks.5 By incorporating a suitable neutral Lewis base XB acceptor, such as pyridine, into a macrocyclic framework, we have also demonstrated that a single charge-assisted XB interaction can be utilized for the templation of a pseudorotaxane assembly and, importantly, in the synthesis of a novel interlocked catenane according to the synthetic strategy outlined in Figure 1.6

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