A New Fundamental Type of Conformational Isomerism
Maxwell Crossley reports on a new fundamental type of conformational isomerism named akamptisomerism.
Isomerism plays a central role in modern chemistry and bio-chemistry. Its initial discovery in 1830 was followed by the revelation of chirality in 1848, the revelation of cis–trans isomerism about double bonds ca. 1890, the isolation of hindered rotamers about single bonds in 1914, and the isolation of hindered invertomers at pyramidal centers in 1961. The groups of Maxwell Crossley from the University of Sydney (Australia) and Jeffrey Reimers (University of Technology Sydney, Australia, and Shanghai University, P. R. of China) describe a new, previously unclassified, fundamental form of conformational isomerism.
The isomerism process was named ‘akamptisomerism’, meaning ‘without bending’, in direct analogy to the name ‘atropisomerism’, which means ‘without turning’, that is applied to name hindered rotamers. In addition, the new stereodescriptors ‘parvo’ and ‘amplo’ were introduced specifying the relationship between the host and its surrounding macrocycle, facilitating unique chemical names for akamptisomers.
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