Arylation of Hydrocarbons Enabled by Organosilicon Reagents and Weakly Coordinating Anions

Hosea Nelson describes a new method to arylate hydrocarbons using organosilicon reagents and very weakly coordinating anions.

Aryl carbocations are not frequently used for intermolecular arylation and alkylation reactions, owing to their high energy, challenging controlled generation and difficulties in taming their reactivity. However, if these problems could be overcome, the use of phenyl carbocations and related intermediates could represent a very efficient and straightforward way to synthesize biaryls and alkyl arenes. 

Recently, the group of Professor Hosea Nelson from the University of California, Los Angeles (USA) reported a breakthrough method for generating and reacting β-silicon-stabilized aryl cation equivalents having very weakly coordinating anions, that can be generated via silylium-mediated fluoride activation.

Read the full article Arylation of Hydrocarbons Enabled by Organosilicon Reagents and Weakly Coordinating Anions 

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