Asymmetric Reaction Screening with a Click Chemistry Sensor

Christian Wolf reports on the quantitative chiroptical sensing of chiral compounds using click chemistry.

The pace of scientific discoveries and developments in academic and industrial laboratories has reached staggering dimensions with the introduction and widespread use of generally available automated high-throughput experimentation equipment. According to Professor Christian Wolf from Georgetown University (USA) the full utilization of high-throughput screening (HTS) methodologies in asymmetric reaction development efforts has been lagging behind for some time. His group has developed an efficient, robust optical method for quantitative chirality sensing of a wide range of substrates. Their coumarin sensor possesses attractive click chemistry features and was successfully applied to asymmetric reaction analysis using only milligram quantities of the crude material.

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