• Case Study: Direct C(sp3)-H Amination for Pyrrolidine Synthesis

    Case Study: Direct C(sp3)-H Amination for Pyrrolidine Synthesis

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Case Study: Direct C(sp3)-H Amination for Pyrrolidine Synthesis

"Our research group is focused on the development of catalytic processes for new amination reactions. In particular, we are interested in the Hofmann–Löffler reaction in which valuable pyrrolidines are the final products. In this case study, we gathered information with the assistance of Science of Synthesis Online about pyrrolidine’s usefulness and plausible routes toward its synthesis through direct C(sp3)-H amination. For the latter, various sections were found to be the most adequate to sum-up all the different processes. The structure tool was used for the searches to afford the results presented here."

Thomas Duhamel, Institute of Chemical Research of Catalonia (ICIQ), Tarragona, Spain

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