Catalytic C–H Arylation of Aliphatic Aldehydes Enabled by a Transient Ligand

Guigen Li and Haibo Ge present the catalytic C–H arylation of aliphatic aldehydes using a transient ligand.

In recent years, significant progress on transition-metal-catalyzed site-selective C–H bond activation has been achieved by introducing directing groups on substrates.1 However, this method has inherent limitations: the process of construction of the original substrates and removal of the directing groups diminishes the efficiency and/or compatibility of the reactions. Therefore, there is a demand for developing a process without installing a directing group. 

The groups of Professor Guigen Li from Nanjing University (P. R. of China) and Professor Haibo Ge from Indiana University–Purdue University Indianapolis (IUPUI, USA) are aiming to design a specific catalyst as a transient directing group that can bind reversibly to the substrate and the metal center.

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