From left: D. V. Horváth, F. Domonyi (copied in), Dr. R. Palkó, Dr. T. Soós, A. Lomoschitz (Hungarian Academy of Sciences, Budapest, Hungary)zoom
Conceptually New Approach to Ellipticine and the Oxoaporphine Core
Regioexhaustive Functionalization of the Carbocyclic Core of Isoquinoline: Concise Synthesis of Oxoaporphine Core and Ellipticine: D. V. Horváth, F. Domonyi, R. Palkó, A. Lomoschitz, T. Soós
Synthesis 2018, DOI: 10.1055/s-0037-1609153
The regioexhaustive functionalization strategy, which was originally introduced by Schlosser, was devised to generate structural diversity utilizing an aromatic or heteroaromatic substrate via iterative and selective metalation reactions, followed by the introduction of protective Cl or TMS groups used to ‘site-silence’ these reactive positions. A novel use of the strategy was recently reported by the group of Dr. Tibor Soós at the Hungarian Academy of Sciences (Budapest, Hungary).
Synthesis of the oxoaporphine core and ellipticinezoom