• Maurizio Benaglia beschreibt die Synthese von chiralen 1,2-Diaminoderivaten unter kontinuierlichem Fluss.

    From left: Dr. M. Pirola, Dr. A. Puglisi, Prof. M. Benaglia, Prof. L. Raimondi (Università degli Studi di Milano, Italy)

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Continuous-Flow Synthesis of Chiral 1,2-Diamino Derivatives

Maurizio Benaglia describes the synthesis of chiral 1,2-diamino derivatives under continuous flow.

A Continuous-Flow, Two-Step, Metal-Free Process for the Synthesis of Differently Substituted Chiral 1,2-Diamino Derivatives: M. Pirola, M. E. Compostella, L. Raimondi, A. Puglisi, M. Benaglia
Synthesis 2018, DOI: 10.1055/s-0036-1591911


Stereo-defined vicinal diamines are valuable building blocks and widespread functional units in bioactive compounds. The use of continuous-flow chemistry is particularly attractive for the preparative synthesis of a wide range of molecules, and recently the group of Professor Maurizio Benaglia (Università degli Studi di Milano, Italy) described an efficient stereoselective approach to 1,2-diamino derivatives using this technology.

  • Maurizio Benaglia describes the synthesis of chiral 1,2-diamino derivatives under continuous flow.

    Continuous-flow synthesis of chiral 1,2-diamino derivatives

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Professor Benaglia said: “In the attempt to realize a two-step, continuous-flow process for the synthesis of differently functionalized chiral 1,2-diamines, the enantioselective, metal-free catalytic reduction of nitro enamines was successfully accomplished for the first time in micro- and mesoreactors (>90% ee). The work is a further demonstration that the development of a multistep continuous-flow process for the synthesis of enantiomerically pure products is today feasible and many new applications will appear in the near future.”
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