From left: Dr. M. Pirola, Dr. A. Puglisi, Prof. M. Benaglia, Prof. L. Raimondi (Università degli Studi di Milano, Italy)zoom
Continuous-Flow Synthesis of Chiral 1,2-Diamino Derivatives
Maurizio Benaglia describes the synthesis of chiral 1,2-diamino derivatives under continuous flow.
A Continuous-Flow, Two-Step, Metal-Free Process for the Synthesis of Differently Substituted Chiral 1,2-Diamino Derivatives: M. Pirola, M. E. Compostella, L. Raimondi, A. Puglisi, M. Benaglia
Synthesis 2018, DOI: 10.1055/s-0036-1591911
Stereo-defined vicinal diamines are valuable building blocks and widespread functional units in bioactive compounds. The use of continuous-flow chemistry is particularly attractive for the preparative synthesis of a wide range of molecules, and recently the group of Professor Maurizio Benaglia (Università degli Studi di Milano, Italy) described an efficient stereoselective approach to 1,2-diamino derivatives using this technology.
Continuous-flow synthesis of chiral 1,2-diamino derivativeszoom