Expeditious Diastereoselective Synthesis of Elaborated Ketones via Remote Csp3–H Functionalization

Cristina Nevado used remote Csp3–H functionalization to synthesize elaborated ketones diastereoselectively.

Selective C–H functionalization reactions offer new strategic opportunities for the rapid assembly of molecular complexity. However, and despite substantial efforts particularly in the field of transition-metal catalysis, examples of non-directed, remote Csp3–H activation to forge complex carbon frameworks remain scarce due to the kinetic stability and thus intrinsic challenge associated with the chemo-, regio- and stereoselective functionalization of aliphatic C–H bonds. 

Professor Cristina Nevado at the University of Zurich (Switzerland) is interested in exploring new research avenues in the area of selective C–H bond activation.

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