Directed beta-C−H Amination of Alcohols via Radical Relay Chaperones

David Nagib presents a new way for a direct beta-C–H amination of alcohols via radical relay chaperones.

The 1,2-hydroxyamino unit is ubiquitous in natural compounds and pharmacologically active molecules, thus representing a major synthetic target in organic chemistry. Although a number of syntheses of beta-amino alcohols are available, chemists still devote considerable efforts towards developing novel strategies for improving atom economy, expanding the scope and maximizing the environmental sustainability of the methods for producing this key structural unit.

Recently, a new paper describing an innovative radical-mediated approach that enables the beta-C–H amination of alcohols, which represents the first example of the ‘radical relay chaperone’ concept, was published by the group of Professor David A. Nagib at The Ohio State University (Columbus, USA).

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