Dual Catalysis for Enantioselective Convergent Synthesis of Enantiopure Vicinal Amino Alcohols

Pei-Qiang Huang and Xin Lu describe the convergent synthesis of enantiopure vicinal amino alcohols.

Enantiopure vicinal amino alcohols and derivatives are essential structural motifs in natural products and pharmaceutically active molecules and serve as main stereogenic sources in asymmetric synthesis. Despite numerous efforts devoted to synthesizing these highly valuable compounds, general catalytic enantioselective methods featuring high efficiency and selectivity and, most importantly, broad substrates scopes are still rare, thus representing a challenging endeavor to organic chemists. Recently, based on a visible-light-induced dual catalytic strategy, a highly effective cross-coupling of nitrones with aromatic aldehydes to give enantiopure vicinal amino alcohols has been demonstrated by Professor Pei-Qiang Huang’s group in collaboration with the theoretical group led by Professor Xin Lu, both at Xiamen University (P. R. of China).


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