Dual Nickel and Lewis Acid Catalysis for Cross-Electrophile Coupling: The Allylation of Aryl Halides with Allylic Alcohols

Xing-Zhong Shu describes the allylation of aryl halides with allylic alcohols using dual catalysis.

Cross-electrophile coupling provides an attractive approach to combine two different bench-stable electrophiles (aryl/alkyl halides, etc.), avoiding the use of air- and/or moisture-sensitive organometallic reagents (RMgX, RZnX, RSnR′3, RB(OH)2, etc.). Thus, it is an interesting alternative to classic cross-coupling reactions, offering a unique opportunity to discover new reactivity and selectivity within this field of organic synthesis. However, control of selectivity for the cross-product is very difficult, which has restricted the widespread use of this versatile method severely. The strategy described in a recent article from the lab of Professor Xing-Zhong Shu at Lanzhou University (P. R. of China) provides a practical solution for overcoming this selectivity challenge in the cross-electrophile coupling of unreactive C–O/N electrophiles.

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