Biocatalytic Site- and Enantioselective Oxidative Dearomatization of Phenols

Alison Narayan describes a biocatalytic, selective method for the oxidative dearomatization of phenols.

Improving selectivity in the oxidation of complex molecules continues to motivate synthetic chemists to devise innovative new strategies and reagents. The oxidative dearomatization of phenols to afford quinol products is one transformation that presents both site- and stereoselectivity challenges, with the opportunity to hydroxylate at either the ortho-position or the para-position relative to the phenolic hydroxyl group. The group of Professor Alison Narayan at the University of Michigan (Ann Arbor, USA) recognized the utility of this transformation and sought to develop a selective catalytic method for the generation of quinol products.

Read the full article Biocatalytic Site- and Enantioselective Oxidative Dearomatization of Phenols

Get Trial Access to the chemistry journals
Download SYNFORM or read it online