From left: C. R. Walters, D. M. Szantai-Kis, Prof. E. J. Petersson, T. M. Barrett (E. M. Hoang not pictured) (University of Pennsylvania, USA); a statue of the University of Pennsylvania’s founder, Benjamin Franklin, is seen in the backgroundzoom
Improved Fmoc Deprotection Methods for the Synthesis of Thioamide-Containing Peptides and Proteins
James Petersson presents the Fmoc deprotection for peptides and proteins containing thioamides.
Thieme Chemistry Journals Awardees – Where Are They Now? Improved Fmoc Deprotection Methods for the Synthesis of Thioamide-Containing Peptides and Proteins: D. M.
Synlett 2017, 28, DOI: 10.1055/s-0036-1589027
Site-specific incorporation of thioamide bonds as bioisosteric replacement of native peptide (amide) bonds is a very useful strategy for producing peptide and protein mimics having distinctive biological, structural and
Fmoc deprotection for thioamide-containing peptides and proteinszoom
Professor Petersson said: “Our new synthetic protocol will improve yields of thioamide modifications in peptides and proteins, enabling a variety of applications, from fluorescence biophysics studies of protein folding to stabilizing therapeutic peptides in vivo.”