• Web seminar
  • Nobel Prize Benjamin List

Web seminar

Powering Molecular Transformers with High Quality Data

  • Web seminar Web seminar

    Web seminar

    Powering Molecular Transformers with High Quality Data

  • Nobel Prize Benjamin List Congratulations!


    A huge shout-out to Ben List and David MacMillan, both members of the Thieme Chemistry family, for receiving the 2021 Nobel Prize in Chemistry. We are thrilled!

  • SYNTHESIS Best Paper Award Winners 2020

    SYNTHESIS Best Paper Award Winners 2020

    Prof. Motomu Kanai, Dr. Kounosuke Oisaki and Kentaro Sakai are the recipients of the SYNTHESIS Best Paper Award 2020.

  • SYNLETT Best Paper Award Winners 2020

    SYNLETT Best Paper Award Winners 2020

    Dr. Philip Kraft, Prof. Quanrui Wang and Prof. Sereina Riniker, together with their co-authors, are the recipients of the SYNLETT Best Paper Award 2020.


IBM Research Europe, Science of Synthesis and Synfacts

Cooperation brings together machine learning and expert human-curated data with unprecedented results in synthesis reaction planning

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Powering Molecular Transformers with High Quality Data. Sign up now!

16.11.2021 Novel Nickel-Catalyzed Synthesis of (Trifluoromethyl)quinolines

T. Kurahashi and S. Matsubara show a new synthetic route to (trifluoromethyl)quinolines.

16.11.2021 Synthesis of Quaternary α-Fluoronitriles from Monofluorolkenes

Xi-Sheng Wang describes the cobalt-catalyzed hydrocyanation of monofluoroalkenes.

16.11.2021 Stereoselective Synthesis of (–)-Heliannuol E

Narihito Ogawa reports on the synthesis of (–)-heliannuol E by selective propargyl substitution.

12.11.2021 SOS Author Spotlight: Oleksandr Grygorenko and Bohdan Vashchenko (1,4-Dioxanes)

Methods for the Synthesis and Modification of 1,4-Dioxanes Compiled and Reviewed for SOS

Nobel Prize Congratulations to the Nobel Prize Winners in Chemistry 2021!

Nobel Prize in Chemistry 2021 has been awarded to Benjamin List and David MacMillan.

01.10.2021 SYNFACTS Editorial Board Update

Prof. Martin Oestreich, TU Berlin (Germany), has joined the SYNFACTS team as editor for the category “Metals in Synthesis”.

01.10.2021 SynOpen welcomes a new crowd review editor!

From now on, Dr. Eduarda Silva, University of Porto (Portugal), takes care of Crowd Review for SynOpen.

17.09.2021 SOS Author Spotlight: Zhi-Shi Ye (Piperazines)

Key Synthetic Routes to Piperazine Structures Comprehensively Reviewed for SOS

13.09.2021 General Entry to Pyrazolo[3,4-b]pyridine-3-carboxamides

John Keating describes the Pd-catalyzed synthesis of pyrazolo[3,4-b]pyridine-3-carboxamides.

26.08.2021 Seven-Step Synthesis of (±)-epi-Costunolide

Yinan Zhang and Lihong Hu present an efficient route for the synthesis of (±)-epi-costunolide.

12.08.2021 Another SOS Crossword is Now Available To Download

Put your knowledge of chemical names to the test!

12.08.2021 SOS Author Spotlight: Vera Vil’, Oleg Bityukov, and Alexander Terent’ev

New Science of Synthesis Review on Acyclic Geminal Bisperoxides

06.08.2021 Total Synthesis of a Microbiologically Important Pentasaccharide

Anup Kumar Misra reports on the synthesis of an important pentasaccharide.

15.07.2021 Synthesis of the Selective Serotonin 2A Receptor Agonist 25CN-NBOH

Jesper Kristensen describes an improved synthetic method for 25CN-NBOH.

Collaboration between IBM Research Europe and Science of Synthesis

The partnership aims at improving the prediction of chemical reaction results using artificial intelligence and synthesis data from Thieme's digital publication source for organic chemistry – Science of Synthesis.

Are you an early career researcher?

If yes, now is your chance to become part of the Science of Synthesis Early Career Advisory Board and to be networking with internationally renowned chemists!

BBTC Breaking Barriers Through Chemistry (Virtual) Conference

We are happy to announce the 1st Breaking Barriers Through Chemistry Conference on August 2nd-6th, 2021 - promoting collaboration with Mexican scientists from all areas of chemistry.

27.07.2021 Science of Synthesis Knowledge Updates - New Volume Editor Appointed

Professor Jean-Marc Campagne is welcomed to the team!

HMZ Spectroscopic Methods

Boost your knowledge of modern spectroscopic methods! The textbook has been a standard reference for decades - now available in the 3rd edition.

09.07.2021 SOS Author Spotlight: Hajime Ito and Koji Kubota

Hokkaido University Researchers Review Borylative Ring Closure

Science of Synthesis Free Radicals: Fundamentals and Applications in Organic Synthesis 07.07.2021 Science of Synthesis Free Radicals: Fundamentals and Applications in Organic Synthesis

Radical chemistry is undergoing a renaissance, both in the selective generation of organic radicals and in their use in organic synthetic reactions.

25.06.2021 Synthesis of Ar-SF4Cl and Ar-SF5 Compounds from Arylphosphorothiolates

Josep Cornella reports on the introduction of tetra- and pentafluorosulfanyl groups into aryl compounds.

Professor Ei-ichi Negishi 24.06.2021 Thieme Chemistry mourns the loss of Prof. Ei-ichi Negishi

Eminent chemist and Science of Synthesis author Ei-ichi Negishi passed away on June 6th, 2021.

Professor Tim Donohoe 24.06.2021 Science of Synthesis Knowledge Updates – New Editor for Hetarene Content

Professor Tim Donohoe joins the Science of Synthesis Editor Team.

15.06.2021 Entry to N-Protected Serine/Threonine-Derived Weinreb Amides

Naoyuki Shimada describes the synthesis of various derived Weinreb amides.

15.06.2021 Oxa-(4+4)-Cycloaddition Entry to Oxazocine Scaffolds

Julian Garrec and Alexis Archambeau present the Pd-catalyzed synthesis of oxazocine scaffolds.

Professor Stanislav Wnuk — SOS Author for Chapter 16.17 28.05.2021 Science of Synthesis Update on Purines

Recent developments in purine synthesis have been reviewed by Professor Stanislav Wnuk and colleagues.

17.05.2021 Concise Total Synthesis of (+)-Aphanorphine

Yukun Guan reports on the total synthesis of (+)-aphanorphine.

04.05.2021 Synthesis of Allyl Aryl Sulfones from Morita–Baylis–Hillman Adducts and Thiosulfonates

Raju Jannapu Reddy presents an efficient synthesis of allyl aryl sulfones.

29.04.2021 Fe(III)-Catalyzed Synthesis of 1-Chalcogenylated Naphthalene Derivatives

Daniel Rampon describes the Ir(III)-catalyzed chalcogenylation of naphthalene derivatives.

29.04.2021 Catalytic Synthesis of Olivetol and Derivatives

James McNulty presents a catalytic, oxidative synthesis of olivetol and various derivatives.

29.04.2021 SYNTHESIS welcomes a new editor!

Prof. Corinna Schindler, University of Michigan (USA), has joined the Editorial Board of SYNTHESIS.

23.09.2021 Pharmaceutical Substances 4.11 is released

Syntheses, patents and applications of drugs are accessible in an easy-to-use online version. Update 4.11 provides 26 new APIs.

Dr. Narendra Ambhaikar 13.04.2021 Science of Synthesis Phenazines Update

Dr. Narendra Ambhaikar reviews recent synthetic routes to phenazine structures

06.04.2021 Nickel-Catalyzed Synthesis of Benzofuran Derivatives

Chen-Liang Deng describes the Ni-catalyzed intramolecular nucleophilic addition of aryl halides to aryl ketones.

23.03.2021 SYNTHESIS welcomes a new editor!

Prof. Martin Oestreich, TU Berlin (Germany), joins the Editorial Board of SYNTHESIS.

08.03.2021 Synthesis of Fluorenone-Fused Coumarins

Mohanad Shkoor synthesizes fluorenone-fused coumarins via DMPA catalysis.