• Wei Han describes the iodide-catalyzed carbonylation–benzylation of benzyl chlorides.

    Prof. W. Han (Nanjing Normal University, P. R. of China)

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Iodide-Catalyzed Carbonylation–Benzylation of Benzyl Chlorides

Wei Han describes the iodide-catalyzed carbonylation–benzylation of benzyl chlorides.

Iodide-Catalyzed Carbonylation–Benzylation of Benzyl Chlorides with Potassium Aryltrifluoroborates under Ambient Pressure of Carbon Monoxide: W. Han, J. Chen, F. Jin, X. Yuan
Synlett 2017, DOI: 10.1055/s-0036-1591502

The carbonylative Suzuki tricomponent reaction is a powerful and versatile methodology for the synthesis of ketones; however, it normally requires the use of metal catalysts, which are often expensive, require carefully controlled conditions and are generally problematic environmentally. The group of Professor Wei Han from Nanjing Normal University (P. R. of China) has recently reported a new way to perform this carbonylative reaction by using a metal-catalyst-free procedure.

  • Wei Han describes the iodide-catalyzed carbonylation–benzylation of benzyl chlorides.

    Synthesis of 1,2,3-triarylpropan-1-ones by iodide-catalyzed carbonylation–benzylation

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Professor Han said: “This conceptually distinct approach toward the direct utilization of gaseous CO represents a significant improvement over the traditional palladium-catalyzed carbonylation:  the catalyst TBAI is abundant, inexpensive, and bench-stable, the reaction conditions are much milder, and the use of ligands and the costly need to remove metallic impurities from the final products are avoided.”
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