Cross-Coupling of Aryl Bromides with Aryl Triflates

The ‘classical’ Ullmann reaction is the copper-catalyzed synthesis of symmetric biaryls from aryl halides. Variants of this reaction based on a single metal catalyst have been the object of intensive studies as a means of producing more complex and non-symmetrical biaryls. According to Professor Daniel Weix from the University of Rochester, New York (USA) the multimetallic catalyzed cross-Ullmann reaction is a general method to access unsymmetrical biaryls from widely available starting materials and a guiding principle for the cooperation of two metal catalysts in coupling reactions. The new cross-Ullmann method recently identified by the Weix group enables the cross-coupling of aryl bromides with aryl triflates with high selectivity and functional group tolerance.

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