Enantioselective Hydrogenation of α-Acetoxy β-Enamido Esters

Asymmetric hydrogenation of polysubstituted enamides has become one of the most powerful strategies for the stereocontrolled synthesis of non-racemic chiral amines, amino acids and their derivatives. Due the strong steric hindrance, the hydrogenation of tetrasubstituted enamides is very challenging and only a few special tetrasubstituted enamides have been effectively obtained in an enantioselective manner. Therefore, the development of an efficient method for synthesizing multifunctionalized chiral amines via hydrogenation of tetrasubstituted enamides was highly desirable and could be achieved by the group of Professors Xume Zhang and Hui Lv (Wuhan University, P. R. of China).

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