Enantioselective Intermolecular Enamide–Aldehyde Cross-Coupling
Chiral amines, amino alcohols, amino acids and their derivatives are very important classes of compounds in nature and in biomolecular research. Furthermore, they are very common and important versatile chiral building blocks for the synthesis of chiral ligands, materials, biologically active compounds and drugs. However, the synthesis of these compounds – especially in stereochemically pure form – can still represent a challenging endeavor. Recently, the group of Professor Jian Wang at the University of Tsinghua (P. R. of China) has reported an efficient method for accessing valuable N-acyl-protected amine derivatives in good yields and with high stereochemical purities through an enantioselective intermolecular enamide–aldehyde cross-coupling catalyzed by chiral N-heterocyclic carbenes.
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