Enantioselective Synthesis of ᴅ-ɑ-Amino Amides

The development of a synthesis platform that provides access to any non-natural amino amide, with either configuration (ʟ or ᴅ), in a peptide context is an overarching goal of Professor Jeffrey N. Johnston’s group at Vanderbilt University (Nashville, USA). In order to make such a platform universally interesting and adoptable, it needs to be based mostly on inexpensive starting materials that vary broadly in structure, provide the ɑ-amino amide product in just a few steps, and be highly stereoselective. Professor Johnston’s work is a significant step in that direction, providing relatively general access to ᴅ-ɑ-amino amides bearing alkyl side chains.

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