Highly Enantioselective Synthesis of 3,4-Dihydropyrans
Phosphine-catalyzed cyclization reactions are of enormous synthetic value, evidenced by ubiquitous presence of ring structures in natural products and bioactive molecules. Over the last few years, the group of Professor Yixin Lu at the National University of Singapore has been interested in developing novel and versatile organic catalysts that can be readily derived from amino acids. One of the main research efforts of his group is to devise powerful approaches to access chiral ring motifs, especially those structures that are not yet accessible via existing methods, and the dihydropyrans synthesized in the highlighed paper are important skeletons of biological significance.
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