Metal-Free Oxidation of Primary Amines to Nitriles

Although the oxidation of primary amines would be, in principle, a straightforward and atom-economical entry to nitriles, the reaction is not conventionally used because of the difficulties connected with controlling the many different oxidation pathways that can originate from amines. Recently, the group of Professor William F. Bailey at the University of Connecticut (USA) has described a novel efficient strategy for accomplishing this challenging transformation.

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