Ring-Opening/Alkynylation of Cyclopropanols

Alkynes are important structural motifs in natural products and functional materials as well as fundamental building blocks in synthetic chemistry and materials science. Among them, internal alkyl alkynes are readily prepared by the Sonogashira cross-coupling reaction of halides with terminal alkyl alkynes. However, the majority of these transformations are limited to aryl electrophiles which often require a copper co-catalyst, a base and a ligand to improve the yield, all of which complicate the procedure for organic synthesis and represent a severe disadvantage for industrial applications. To overcome these disadvantages, the group of Professor Jin-Heng Li and Dr. Ye-Xiang Xie aim to develop new strategies involving the use of new electrophilic alkynylating reagents for producing diverse alkyl alkynes.

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