Synthesis of Chiral Heterocycles

Synthesis of Chiral HeterocyclesControlling the regioselectivity of an organic reaction at one’s discretion while also maintaining full control of the stereochemistry of the process is a luxury in organic synthesis and not many methods are known for achieving such an out-standing level of control in the generation of stereogenic allylic systems. Recently, Professor Dennis Hall and co-workers at the University of Alberta (Canada) described the first example of a Suzuki–Miyaura cross-coupling with allylic boronates where both the configuration of an sp3 carbon (stereoselectivity) and the regioselectivity of the coupling process are fully controlled by the catalyst and especially the nature of the ligand.

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