Catalytic Formal [2+2+1] Synthesis of Pyrroles
Polysubstituted pyrroles are very common and important structural motifs in many biologically active compounds, drugs and materials, but the synthesis of these compounds is often very challenging. Recently, the group of Professor Ian A. Tonks at the University of Minnesota – Twin Cities (USA) has reported a groundbreaking and efficient method for accessing pyrroles having up to five substituents on the ring through a formal [2+2+1] cyclization of alkynes and diazenes promoted by a Ti(II)/Ti(IV) redox catalytic cycle.
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