Synthesis of Seven-Membered-Ring-Containing Polycycles

The synthetic efficiency for the construction of the fused 5,7,6-tricyclic skeleton of certain bioactive diterpenes by traditional step-by-step strategies is usually low. The group of Professor Zhi-Xiang Yu from Peking University (Beijing, P. R. of China) discovered and developed a gold(I)-catalyzed tricyclization for the diastereoselective synthesis of the challenging fused 5,7,6-tricyclic system of the target diterpenes from linear dienediynes. This cascade reaction occurs via a complex multistep sequence to yield the target skeletons with high diastereocontrol.

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