Total Synthesis of (±)-Alstoscholarisine A
Alzheimer’s, Parkinson’s and Huntington’s disorder, as well as amyotrophic lateral sclerosis, are the most common examples of currently incurable neurodegenerative diseases, characterized by a progressive loss of neuronal function. In recent years, it has been realized that small molecules could promote adult neuronal stem cell (NSC) proliferation and differentiation, which could potentially have important therapeutic applications for addressing unmet medical needs such as neurodegeneration. In 2014, five indole alkaloids were isolated from Alstonia scholaris, and alstoscholarisine A was shown to significantly promote adult NSC proliferation and differentiation. Professors Filip Bihelovic and Zorana Ferjancic at the University of Belgrade (Serbia) were also impressed by the unique molecular structure of alstoscholarisine A and therefore started a synthetic project aiming to develop a concise yet flexible synthesis of this molecule.
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