• Scott Denmark gives insight into the mechanism of the bromocycloetherification of alkenes.

    From left: Prof. S. E. Denmark, Dr. D. Böse (University of Illinois at Urbana-Champaign, USA)

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Mechanistic Insight on the Bromocycloetherification of Alkenes

Scott Denmark gives insight into the mechanism of the bromocycloetherification of alkenes.

Investigating the Enantiodetermining Step of a Chiral Lewis Base Catalyzed Bromocycloetherification of Privileged Alkenes: D. Böse, S. E. Denmark
Synlett 2018, DOI: 10.1055/s-0036-1590951


Enantioselective halofunctionalizations of alkenes are useful and sophisticated reactions leading to a wide range of chiral non-racemic compounds, for example halogenated δ- and γ-lactones. An in-depth understanding of the mechanism of these complex processes, in particular when Lewis-base catalysis is involved, is a key requirement for optimizing the reaction outcome and design. The group of Professor Scott E. Denmark from the University of Illinois at Urbana-Champaign (USA) has recently reported an important contribution which provides further insight and improves design criteria on the process.

  • Scott Denmark gives insight into the mechanism of the bromocycloetherification of alkenes.

    Enantio- and diastereoselective synthesis of cyclic ethers

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Professor Denmark said: “We have elucidated the remarkable behavior of 1,1-disubstituted alkenes to function as privileged substrates for enantioselective bromoetherification; read this paper to find out why!”
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