• Geoffrey Tranmer describes the metal-free primary amination of potassium aryltrifluoroborates and phenylboronic acids.

    Prof. G. Tranmer (right) and his group (University of Manitoba, Canada)

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Metal-Free Primary Amination of Potassium Aryltrifluoroborates and Phenylboronic Acids

Geoffrey Tranmer describes the metal-free primary amination of potassium aryltrifluoroborates and phenylboronic acids.

Sonication and Microwave-Assisted Primary Amination of Potassium Aryltrifluoroborates and Phenylboronic Acids under Metal-Free Conditions: D. Kuik, J. A. McCubbin, G. K. Tranmer
Synthesis 2017, 49, DOI: 10.1055/s-0036-1588148

The arylamine moiety is very common in drugs, bioactive compounds and natural products; therefore, it continues to represent a very important synthetic target in organic chemistry. Recently, the group of Professor G. K. Tranmer at the University of Manitoba (Canada) published a new method applicable to the synthesis of a wide array of arylamine substrates based on a general functional group interconversion that will likely be of interest to a broad audience of researchers having an interest in generating aromatic C–N bonds.

  • Synthesis of various arylamines

    Synthesis of various arylamines

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Professor Tranmer said: “The manuscript describes the development of the first general method – providing rapid access to primary arylamines using inexpensive reagents in good to excellent yields under mild conditions – for the conversion of aryltrifluoroborates (ArBF3K) and boronic acids [PhB(OH)2] to aromatic primary amines (ArNH2) under mild, metal-free conditions using microwave or sonication reaction processing.”

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