• Jiaan Shao and Wenteng Chen present the synthesis of polysubstituted 2-aminopyrroles.

    From left: Prof. J. Shao, Prof. W. Chen (Zhejiang Sci-Tech University and Zhejiang University, Hangzhou, P. R. of China)

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Multicomponent Entry to Polysubstituted 2-Aminopyrroles

Jiaan Shao and Wenteng Chen present the synthesis of polysubstituted 2-aminopyrroles.

Highly Efficient Synthesis of Polysubstituted 2-Aminopyrroles via a Multicomponent Domino Reaction: J. Shao, D. Ke, K. Shu, E. Chen, Y. Yu, W. Chen
Synlett 2018, DOI: 10.1055/s-0036-1591907


Multicomponent domino reactions are important tools in organic chemistry, as they enable one-pot access to complex and differently functionalized libraries of molecules in a straightforward and efficient manner. A new application of the multicomponent methodology has been recently reported by the group of Professor Wenteng Chen from Zhejiang University in Hangzhou (P. R. of China).

  • Jiaan Shao und Wenteng Chen präsentieren die Synthese polysubstituierter 2-Aminopyrrole.

    Synthesis of polysubstituted 2-aminopyrroles via a multicomponent domino reaction

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Professor Chen said: “A highly efficient approach to polysubstituted 2-aminopyrroles containing a coumarin derivative unit at the 5-position of the pyrrole ring was developed via a novel multicomponent domino reaction of glyoxal monohydrate derivatives, anilines, coumarin derivatives, and malononitrile.”
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