• Paul Kosma introduces new heptitol derivatives with potential antibiotic properties.

    From left: Prof. P. Kosma, Dr. M. Blaukopf (University of Natural Resources and Life Sciences, Vienna, Austria)

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New Heptitol Derivatives as Potential Antibacterials

Paul Kosma introduces new heptitol derivatives with potential antibiotic properties.

Synthesis of 1,5-Anhydro-D-glycero-D-gluco-heptitol Derivatives as Potential Inhibitors of Bacterial Heptose Biosynthetic Pathways: M. Blaukopf, D. Atamanyuk, N. M. Xavier, V. Gerusz, P. Kosma
Synthesis 2017, DOI: 10.1055/s-0036-1591518


The discovery of novel antibiotic compounds represents a current priority in health sciences, owing to the global emergency constituted by a growing resistance to currently used antibacterial therapies. The search for new compounds targeting receptors and pathways specific for bacteria – and not expressed on, or used by human cells – is therefore a fundamentally important research area. Recently, the group Professor Paul Kosma at the University of Natural Resources and Life Sciences (Vienna, Austria) has reported the development of new potential molecular tools for tackling bacterial infections.

  • Paul Kosma introduces new heptitol derivatives with potential antibiotic properties.

    Synthesis of heptitol derivatives

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Professor Kosma said: “The paper explores options to develop novel antimicrobials targeting central enzymes involved in the biosynthesis of higher-carbon sugars as components of Gram-negative bacterial cell wall polysaccharides.”
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