Organocatalytic Enantioselective Synthesis of 1,3-Disubstituted Allenols
Dimethylprolinol Versus Diphenylprolinol in CuBr2-Catalyzed Enantioselective Allenylation of Terminal Alkynols: D. Ma, X. Duan, C. Fu, X. Huang, S. Ma
Synthesis 2018, DOI: 10.1055/s-0036-1592007
Axially stereogenic allenes are important compounds in organic chemistry both for their usefulness as synthetic intermediates and because several natural substances belong to this family of cumulene derivatives. Recently, the group of Professor Shengming Ma at Zhejiang University (P. R. of China) reported a versatile organocatalyzed process for accessing 1,3-disubstituted allenes with a high degree of enantiocontrol.