Oxime Ligation via in situ Oxidation of N-Phenylglycinyl Peptides

Caroline Proulx achieved oxime ligation by oxidizing N-phenylglycinyl peptides in situ.

The selective formation of covalent bonds in complex biological settings requires the discovery and optimization of high-yielding bio-orthogonal chemical transformations. While many different bioconjugation reactions are available, advances in existing methods are often necessary to increase their scope and utility. In this recent publication, the group of Professor Caroline Proulx at North Carolina State University (Raleigh, USA) sought to address some of the known limitations that exist with oxime ligation reactions, where amino-oxy residues react selectively with α-oxo aldehydes to form stable covalent bonds.

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