• Photoredox Synthesis of Arylhydroxylamines

    From left: L. Angelini, Dr. D. Leonori, J. Davies (University of Manchester, UK); M. A. Alkhalifah, Prof. N. S. Sheikh (King Faisal University, Saudi Arabia)

      zoom

Photoredox Synthesis of Arylhydroxylamines

Daniele Leonori reports on a practical photoredox method to synthesize arylhydroxylamines.

Photoredox Synthesis of Arylhydroxylamines from Carboxylic Acids and Nitrosoarenes: J. Davies, L. Angelini, M. A. Alkhalifah, L. Malet Sanz, N. S. Sheikh, D. Leonori
Synthesis 2018, 50, 821–830


Hydroxylamines are important compounds as they can be used as intermediates for a number of organic transformations; furthermore, the hydroxylamine function is widespread in biologically active molecules and natural compounds. However, the synthesis of hydroxylamines still represents a challenge for organic chemists. Recently, the group of Dr. Daniele Leonori from the University of Manchester (UK) reported a new and practical method for achieving the synthesis of the title compounds.

  • Daniele Leonori reports on a practical photoredox method to synthesize arylhydroxylamines.

    Photoredox synthesis of arylhydroxylamines

      zoom
Dr. Leonori said: “Hydroxylamines are synthetically relevant building blocks in organic chemistry, here we show how to prepare them from readily available carboxylic acids via a decarboxylative photoredox protocol to obtain structurally complex and poly-functionalized substrates.”
Get Trial Access to the chemistry journals
Download SYNFORM or read it online