New Radiochemical Synthesis of the PET Tracer 2-[18F]Fluorophenylalanine

2-[18F]Fluorophenylalanine: Synthesis by Nucleophilic 18F-Fluorination and Preliminary Biological Evaluation: D. J. Modemann, B. D. Zlatopolskiy, E. A. Urusova, J. Zischler, A. Craig, J. Ermert, M. Guliyev, H. Endepols, B. Neumaier
Synthesis 2019, 51, 664–676

PET (Positron Emission Tomography) is a powerful imaging technique that has enormous potential in personalized medicine and vitally important applications as a diagnostic method as well as a tool in drug development. PET is based on the administration of radioactive tracers incorporating short-lived nuclides such as [18F]fluorine. 2-[18F]Fluorophenylalanine is a promising tracer that has already found applications in oncology and neuro-imaging. The group of Professor Bernd Neumaier from the Institut für Neurowissenschaften und Medizin at the Forschungszentrum Jülich GmbH (Germany) recently reported a new efficient radiosynthesis of this tracer.

Professor Neumaier said: "This work reports the novel efficient procedure for the racemization-free preparation of 2-[18F]FPhe using Cu-mediated radiofluorination under ‘minimalist’ conditions which may have important implications for the production of other clinically useful PET probes like 6-[18F]FDOPA and 6-[18F]FMT.”
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