Rearrangement to Electron-Deficient Nitrogen: August Wilhelm von Hofmann (1818–1892), Wilhelm Lossen (1838–1906) and Theodor Curtius (1857–1928)

This Name Reaction Biography presents August Wilhelm von Hofmann, Wilhelm Lossen, and Theodor Curtius.

Between 1872 and 1890, three closely related reactions that involve a stereoselective (or stereospecific) rearrangement of an alkyl group from an acyl carbon to nitrogen were reported by Wilhelm Clemens Lossen, who reported a base-promoted rearrangement of hydroxamic acid derivatives, by August Wilhelm von Hofmann, who reported the base-promoted rearrangement of N-haloamides, and by Geheimrat Julius Wilhelm Theodor Curtius, who reported the rearrangement of acyl azides.


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