Case Study: Alexander Preinfalk, Institute of Organic Chemistry, University of Viennazoom
Case Study: Enantioconvergent Cross-Coupling of Racemic Secondary Organozinc Reagents
"Among a range of topics, we work on asymmetric palladium catalysis for deracemization reactions. Over the last few years we have become particularly interested in the use of chiral racemic secondary organozinc compounds for such transformations. These compounds show remarkable functional group tolerance compared to other classes of organometallic reagents, such as organolithium or Grignard reagents. However, the high degree of covalency of the carbon–zinc bond and the resulting slower rate of racemization compared to the more ionic organolithium or Grignard reagents constitutes a major challenge for deracemization reactions (Scheme 1). To overcome this hurdle and find a suitable catalyst system, a solid knowledge of the background literature is essential. I therefore regularly consult Science of Synthesis Online as a comprehensive source of information and enormously value the high quality of the individual articles accessible with just a few mouse clicks."
Alexander Preinfalk, Institute of Organic Chemistry, University of Vienna
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