Science of Synthesis Original Edition

Science of Synthesis provides a critical review of the synthetic methodology in the fields of organic and organometallic chemistry. This reference work is produced by the collaborative efforts of chemists, from both industry and academia, selected by the Editorial Board and Volume Editors.

Science of Synthesis, Houben–Weyl Methods of Molecular Transformations was launched in 2000 and was edited by D. Bellus (Basel, Switzerland), E. N. Jacobsen (Cambridge, USA), S. V.Ley (Cambridge, UK), R. Noyori (Nagoya, Japan), M. Regitz (Kaiserslautern, Germany), P. J. Reider (Princeton, USA), E. Schaumann (Clausthal-Zellerfeld, Germany), I. Shinkai (Tokyo, Japan), E. J. Thomas (Manchester, UK), and B. M. Trost (Stanford, USA).

The series comprises 48 volumes that were published between 2000 and 2010. It includes 28,000 generally applicable synthetic methods and 250,000 reactions for over 2,700 different kinds of organic compounds.

Science of Synthesis comprises six different categories which are described below.

Science of Synthesis Category 1 SOS Category 1


Science of Synthesis Category 2 SOS Category 2

Hetarenes and Related Ring Systems

Science of Synthesis Category 3 SOS Category 3

Compounds with Four and Three Carbon-Heteroatom Bonds e.g. Nitriles, Isocyanides and Derivatives; Acid Halides; Carboxylic Acids and Acid Salts; Esters, Polyesters, and Lactones; Peroxy Acids; Amides and Derivatives; Lactams; Ketenes

Science of Synthesis Category 4 SOS Category 4

Compounds with Two Carbon-Heteroatom Bonds e.g. Aldehydes; Ketones; Heteroatom Analogues of Aldehydes and Ketones; Quinones and Heteroatom Analogues; Acetals; Arene-X Compounds; X-Ene-X, Ene-Hal, and Ene-O Compounds

Science of Synthesis Category 5 SOS Category 5

Compounds with One-Heteroatom Bond e.g. Alcohols; Peroxides; Sulfides, Selenides, and Tellurides; Amines, Ammonium Salts, Haloamines, Hydroxylamines, and Hydrazines; Organophosphorous Compounds

Science of Synthesis Category 6 SOS Category 6

Compounds with All-Carbon Functions e.g. Polyynes, Arynes, Enynes, and Alkynes; Cumulenes and Allenes; Arenes, Quasiarenes, Annulenes, and Polyenes; 1,3-Dienes; Alkenes and Alkanes

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