Stille Coupling via C–N Bond Cleavage

Masanobu Uchiyama reports on the nickel-catalyzed Stille coupling via C–N bond cleavage.

Biaryls are privileged structures that continue to attract enormous interest for their many applications as drugs and materials. The Stille cross-coupling reaction is one of the most often used methods for assembling biaryls via C–C bond formation between the two aromatic rings. The classical version of this reaction uses aryl stannanes and aryl halides as substrates, while the catalyst is a palladium complex. Recently, the group of Professor Masanobu Uchiyama from The University of Tokyo (Japan) reported the first nickel-catalyzed Stille coupling of quaternary ammonium salts via C–N bond cleavage.

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