Enantioselective Three-Component Aminomethylation of α-Diazo Ketones with Alcohols and 1,3,5-Triazines

Dong Xing and Wenhao Hu present an enantioselective three-component aminomethylation reaction.

β-Amino carbonyl moieties are versatile synthetic building blocks that can be employed toward a wide variety of natural products and biologically active compounds. As an important research branch of the Mannich reaction, the aminomethylation reaction of ketones or aldehydes represents an efficient protocol for accessing β-amino carbonyl compounds. Quoting Professor Dong Xing from East China Normal University (P. R. of China), recent years have witnessed the application of a variety of aminomethylation reagents to the enantioselective variant of the reaction. However, asymmetric induction of these transformations is dominated by using chiral catalysts to activate the nucleophiles, i.e. chiral amines or Lewis acids with chiral ligands. In a long-standing collaboration with the group of Professor Wenhao Hu from the same university, Professor Xing’s group carry out research on carbene-involved enantioselective multicomponent reactions (MCRs) via cooperative catalysis.

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