Asymmetric Three-Component Olefin Dicarbofunctionalization Enabled by Photoredox and Copper Dual Catalysis
Wen-Jing Xiao and Jia-Rong Chen describe a dual-catalyzed asymmetric olefin dicarbofunctionalization.
Alkenes are among the most privileged and versatile compounds in organic synthesis, because a diverse range of functional groups can be readily introduced across the C=C π system by using many well-established and versatile vicinal di-functionalization reactions. In this context, one of the most investigated and fundamental transformations is the intermolecular three-component alkene vicinal di-carbo-functionalization (DCF) reaction, which allows for the installation of two different carbon fragments.
The group of Professors Jia-Rong Chen and Wen-Jing Xiao at Central China Normal University (Wuhan, P. R. of China) has been interested in visible-light photoredox-controlled reactions of iminyl nitrogen radicals and have recently developed a generally applicable visible-light-driven copper-catalyzed radical cross-coupling reaction of cyanoalkyl carbon radicals, which enables the synthesis of diverse distantly functionalized alkyl nitriles.