Chemodivergent Manganese-Catalyzed C–H Activation: Modular Synthesis of Fluorogenic Probes
Lutz Ackermann and Marc Vendrell present the modular synthesis of fluorogenic probes.
In the past few years, environmentally sensitive fluorophores have been developed to image cell-specific events associated to – among others – infection, inflammation and cancer in vivo. However, the vast majority of these strategies rely on elements of substrate pre-functionalization. As a consequence, there is increasing interest in developing new approaches for late-stage fluorogenic labeling of biomolecules with the aim of assembling molecular probes enabling for real-time imaging. In this context, the chemo- and positional-selective modification of biologically relevant compounds is particularly important for the late-stage diversification of biomolecules endowed with new spectral and biological capabilities. The groups of Professor Lutz Ackermann from the Georg-August-Universität Göttingen (Germany) and Professor Marc Vendrell from The University of Edinburgh (UK) engaged in a successful collaboration aimed at advancing the state-of-the-art in the area of fluorogenic probes suitable for real-time in vivo imaging.