Continuous-Flow C(sp3)–H Functionalizations of Volatile Alkanes Using Decatungstate Photocatalysis
Timothy Noël describes a new strategy to convert light alkanes into value-added molecules. via decatungstate photocatalysis.
C(sp3)–H functionalization of alkanes in the absence of proximal directing groups is considered one of the most challenging and important reactions in contemporary synthetic organic chemistry. In particular, the incorporation of light alkanes, such as methane, ethane, propane and butane, into organic molecules is extremely attractive because it would move the perception of these chemicals essentially as fuel materials to potentially valuable synthetic building blocks.
Building on their experience in decatungstate-photocatalyzed C–H oxidations, the group of Professor Timothy Noël at the Eindhoven University of Technology (The Netherlands) focused their attention to this valuable – yet absent in organic synthesis – chemical conversion of gaseous alkanes, which could benefit from continuous-flow microreactor technology.
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