Copper-Enabled Photo-Sulfonylation of Aryl Halides Using Alkylsulfinates
Dan Lehnherr describes the photo-sulfonylation of aryl halides using alkylsulfinates.
Sulfones are prevalent in synthetic organic chemistry and can serve both as functional group handles in synthetic intermediates as well as structural features in bioactive targets. Dr. Dan Lehnherr from the Process Research and Development department of Merck & Co., Inc. (Rahway, New Jersey, USA) explained that “methods of synthesizing sulfones include oxidation of sulfides, metal-catalyzed cross-couplings of sulfinates, direct C–H functionalizations, and three-component couplings using SO2 or its surrogate.” His group was interested in developing novel and efficient strategies for installing sulfonyl groups into organic molecules. They developed a sulfonylation method that provides complementarity to existing photochemical methods of cross-coupling sulfinate salts with aryl halides.
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