Enantioselective Electrochemical Cobalt-Catalyzed Aryl C–H Activation Reactions
Lutz Ackermann describes new cobalt-catalyzed aryl C–H activation reactions.
The three-dimensional absolute configuration of an organic molecule plays a critical role in defining its physical and biological activity. Hence, the stereoselective synthesis of organic compounds is of exceptional importance, especially in the fields of flavors and fragrances, in agrochemistry, as well as in drug development. In this regard, enantioselective catalysis has proven to be a powerful tool and continuous efforts have been devoted to design novel asymmetric transformations and apply them for practical usage. According to Professor Lutz Ackermann (Georg-August-Universität Göttingen, Germany) “transitionmetal-catalyzed C–H activation reactions remained at the forefront, owing to their sustainable nature and broad utility prospects. But a large majority of these transformations make use of expensive and toxic 4d transition metals in combination with sophisticated chiral ligands, which constitutes a considerable limitation.” Professor Ackermann’s research group recently developed a novel approach to this issue, which was published in the title article.
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