Enantioselective Au(I)/Au(III) Redox Catalysis Enabled by Chiral (P,N)-Ligands

Nitin Patil shows how new chiral (P,N)-ligands enable the gold-redox-catalyzed 1,2-difunctionalization of alkenes.

In the past decade, Au(I)/Au(III) redox catalysis has emerged as a new technique, opening avenues for the cross-coupling and 1,2-difunctionalization reactions of C–C multiple bonds that were previously inaccessible with Au(I) or Au(III) catalysis. However, the enantioselective version of Au(I)/Au(III) redox catalysis remained elusive until recently, when the research group of Dr. Nitin Patil (Indian Institute of Science Education and Research Bhopal, India) developed new hemilabile chiral (P,N)-ligands (ChetPhos) to realize the first example of enantioselective Au(I)/Au(III) redox catalysis. Dr. Patil says that “the potential of this concept is demonstrated in gold-catalyzed 1,2-oxyarylation and 1,2-aminoarylation of alkenes leading to medicinally important 3-oxy- and 3-aminochromans with high yields and enantioselectivities. This concept of ligand-enabled enantioselective Au(I)/Au(III) redox catalysis should be applicable to a vast number of cross-coupling reactions and alkene difunctionalization reactions.”

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